HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Pyridinecarbonyl chloride, hydrochloride (1:1) → N-[4-Methyl-3-(2-pyridin-4-yl-6-(trifluoromethyl)pyrimidin-4-ylamino)-phenyl]nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Pyridinecarbonyl chloride, hydrochloride (1:1) | HCID 88438 | — |
| Reactant | 4-(5-Amino-2-methylanilino)-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine | HCID 22732458 | — |
| Product | N-[4-Methyl-3-(2-pyridin-4-yl-6-(trifluoromethyl)pyrimidin-4-ylamino)-phenyl]nicotinamide | HCID 22732504 | — |
Reaction Steps
The title compound was prepared from a mixture of 4-(5-amino-2-methylanilino)-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine (20 mg, 0.058 mmol) and nicotinoyl chloride hydrochloride (10 mg, 0.058 mmol) similar to Example 139 and isolated as a tan solid (13 mg, 47%). 1H NMR (DMSO-d6):
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716851B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-292d1dabf3554f5fbc576bc4c4df31ce |
| Source note | uspto-grants-2004_04 |