Hydrochloric Acid → HCID 22732376, compound

Participants

Reaction Steps

A mixture of 4-chloro-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine (25 mg, 0.096 mmol), 3-trifluoromethoxyaniline (19 μl, 0.144 mmol), and 2N HCl (75 μl) in water:ethanol (2:1, 5 ml) was refluxed for 24 h. The mixture was cooled to room temperature and the resulting precipitate was filtered, washed with water, water:ethanol (2:1) and dried to give a yellow solid (23 mg, 59%). 1H NMR (CDCl3): 8.88-8.85 (m, 1H), 8.59-8.55 (m, 1H), 7.93-7.87 (m, 1H), 7.59 (s, 1H), 7.48 (t, J=8.3 Hz, 1H), 7.45 (dd, J=1.2, 7.5 Hz, 1H), 7.36 (s, 1H), 7.30-7.29 (m, 1H), 7.16-7.10 (m, 1H), 7.05 (s, 1H).

Provenance & Evidence