5-Chloro-2-methoxyaniline → HCID 22732360, compound

HRID 2084206Notes

Reaction equation

HRID 2084206 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[N:3]=1.[Cl:18][C:19]1[CH:20]=[CH:21][C:22]([O:26][CH3:27])=[C:23]([CH:25]=1)[NH2:24]>>[Cl:18][C:19]1[CH:20]=[CH:21][C:22]([O:26][CH3:27])=[C:23]([CH:25]=1)[NH:24][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[N:3]=1

Participants

3

Reactant 2

HCID 667635-Chloro-2-methoxyanilineHCID 14859894-Chloro-2-(pyridin-4-yl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 22732360HCID 22732360, compound

Procedure

The title compound was prepared from 4-chloro-2-(4-pyridinyl)-6-trifluoromethyl-pyrimidine (150 mg, 0.578 mmol) and 5-chloro-2-methoxyaniline (98 mg, 0.621 mmol) similar to Example 160 and was isolated as off-white solid (84 mg, 0.221 mmol, 38%). 1H NMR (CDCl3/MeOH-d4): 8.72 (d, J=4.2 Hz, 2H), 8.51 (s, 1H), 8.34 (d, J=4.5 Hz), 7.09 (m, 2H), 6.91 (d, J=8.4 Hz, 1H), 3.93 (s, 3H)

Sources & evidence

ORD record
ord-f202b46c859f400386039c5fcc2ddefc
Source dataset
uspto-grants-2004_04
Patent number
US06716851B2

Reaction notes

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