6-Chloro-m-anisidine → HCID 22732388, compound

HRID 2084207Notes

Reaction equation

HRID 2084207 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[C:16]([Cl:18])[N:15]=[C:14]([Cl:19])[CH:13]=2)[N:3]=1.[Cl:20][C:21]1[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][C:22]=1[NH2:23]>>[Cl:20][C:21]1[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][C:22]=1[NH:23][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[C:16]([Cl:18])[N:15]=[C:14]([Cl:19])[CH:13]=2)[N:3]=1

Participants

3

Reactant 2

HCID 754606-Chloro-m-anisidineHCID 22732394HCID 22732394, compound

Product 1

HCID 22732388HCID 22732388, compound

Procedure

The title compound was prepared from 4-chloro-2-(2,6-dichloro-4-pyridinyl)-6-trifluoromethyl-pyrimidine (52 mg, 0.159 mmol) and 2-chloro-5-methoxyaniline (40 mg, 0.255 mmol) similar to Example 160 and was isolated as a yellow crystalline solid (13 mg, 0.029 mmol, 18%). 1H NMR (CDCl3): 8.27 (s, 2H), 7.76 (s, br, 1H), 7.40 (s, 1H), 7.38 (s, 1H), 7.02 (s, 1H), 6.77 (m, 1H), 3.90 (s, 3H).

Sources & evidence

ORD record
ord-9c5f2798d6174eeca84a8460ee816304
Source dataset
uspto-grants-2004_04
Patent number
US06716851B2

Reaction notes

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