3-Amino-4-methoxybenzoic acid → HCID 22732396, compound

HRID 2084226Notes

Reaction equation

HRID 2084226 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[N:16][CH:15]=[CH:14][N:13]=2)[N:3]=1.[C:18]([C:21]1[CH:22]=[CH:23][C:24]([O:28][CH3:29])=[C:25]([CH:27]=1)[NH2:26])([OH:20])=[O:19]>>[C:18]([C:21]1[CH:22]=[CH:23][C:24]([O:28][CH3:29])=[C:25]([CH:27]=1)[NH:26][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[N:16][CH:15]=[CH:14][N:13]=2)[N:3]=1)([OH:20])=[O:19]

Participants

3

Reactant 2

HCID 178233-Amino-4-methoxybenzoic acidHCID 227323674-Chloro-2-(2-pyrazinyl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 22732396HCID 22732396, compound

Procedure

The title compound was prepared from 4-chloro-2-(2-pyrazinyl)-6-trifluoromethylpyrimidine (40 mg, 0.154 mmol) and 5-carboxy-2-methoxyaniline (38 mg, 0.231 mmol), similar to Example 180 and was isolated as an off white solid (20 mg, 33%). 1H NMR (CDCl3): 9.99 (brs, 1H), 9.660 (d, J=1.5 Hz, 1H), 8.86 (m, 3H), 7.80 (d, 2H), 7.2 (m, 2 H), 3.94 (s, 3H).

Sources & evidence

ORD record
ord-85962b1305fd4a5d84c629a07bf47f5a
Source dataset
uspto-grants-2004_04
Patent number
US06716851B2

Reaction notes

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