2-Ethylsulfonyl-5-hydroxyaniline → 4-(2-Ethylsulfonyl-5-hydroxyanilino)-2-(2-pyrazinyl)-6-trifluoromethylpyrimidine

HRID 2084228노트

반응식

HRID 2084228 반응식
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[N:16][CH:15]=[CH:14][N:13]=2)[N:3]=1.[CH2:18]([S:20]([C:23]1[CH:29]=[CH:28][C:27]([OH:30])=[CH:26][C:24]=1[NH2:25])(=[O:22])=[O:21])[CH3:19]>>[CH2:18]([S:20]([C:23]1[CH:29]=[CH:28][C:27]([OH:30])=[CH:26][C:24]=1[NH:25][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[N:16][CH:15]=[CH:14][N:13]=2)[N:3]=1)(=[O:22])=[O:21])[CH3:19]

참가 물질

3

반응물 2

HCID 227323572-Ethylsulfonyl-5-hydroxyanilineHCID 227323674-Chloro-2-(2-pyrazinyl)-6-(trifluoromethyl)pyrimidine

생성물 1

HCID 227323524-(2-Ethylsulfonyl-5-hydroxyanilino)-2-(2-pyrazinyl)-6-trifluoromethylpyrimidine

실험 절차

The title compound was prepared from 4-chloro-2-(2-pyrazinyl)-6-trifluoromethylpyrimidine (40 mg, 0.154 mmol) and 2-ethylsulfonyl-5-hydroxyaniline (46 mg, 0.231 mmol) similar to Example 180. The reaction mixture was evaporated under vacuum to give a residue. The residue was precipitated using acetone to give the product as a yellow solid (30 mg, 46%). 1H NMR (DMSO-d6): 9.45 (s, 1H), 8.71 (m, 3H), 7.84 (brs, 1H), 7.0 (brd, 1H), 6.08 (brd, 1H), 3.0 (q, 2H), 1.0 (t, 3H).

후처리

  1. customThe reaction mixture was evaporated under vacuum
  2. customto give a residue
  3. customThe residue was precipitated

출처 및 근거

ORD 기록
ord-17dbc9a9c5004e0e8ea9759ed04d2189
출처 데이터셋
uspto-grants-2004_04
특허 번호
US06716851B2

반응 노트

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