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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2084235Generated: November 1, 2026

3-Amino-p-cresol → HCID 22732487, compound

https://huagongshe.com/reaction/2084235

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Amino-p-cresolHCID 17820—
Reactant4-Chloro-2-(2-pyrazinyl)-6-(trifluoromethyl)pyrimidineHCID 22732367—
ProductHCID 22732487HCID 22732487—

Reaction Steps

The title compound was prepared from 4-chloro-2-(2-pyrazinyl)-6-trifluoromethylpyrimidine (40 mg, 0.154 mmol) and 5-hydroxy-2-methylaniline (34 mg, 0.231 mmol) similar to Example 190 and was isolated as a solid (3 mg). 1H NMR (CDCl3): 9.74 (d, J=1.2 Hz, 1H), 8.76-8.71 (m, 2H), 7.30 (brs, 1H), 7.18 (d, J=8.4 Hz, 1H), 6.87 (brd, 1H), 6.78 (dd, J=8.4, 2.4 Hz, 1H), 6.73 (s, 1H), 2.21 (s, 3H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06716851B2
Source datasetuspto-grants-2004_04
ORD IDord-5c6a9c095c504170b9e8211c4d558165
Source noteuspto-grants-2004_04