2-Amino-4,5-dimethoxybenzonitrile → HCID 22732488, compound

HRID 2084245Notes

Reaction equation

HRID 2084245 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1.[C:18]([C:20]1[CH:26]=[C:25]([O:27][CH3:28])[C:24]([O:29][CH3:30])=[CH:23][C:21]=1[NH2:22])#[N:19]>>[C:18]([C:20]1[CH:26]=[C:25]([O:27][CH3:28])[C:24]([O:29][CH3:30])=[CH:23][C:21]=1[NH:22][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1)#[N:19]

Participants

3

Reactant 2

HCID 7359672-Amino-4,5-dimethoxybenzonitrileHCID 14859904-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 22732488HCID 22732488, compound

Procedure

The title compound was prepared from 4-chloro-2-(3-pyridinyl)-6-trifluoromethylpyrimidine (50 mg, 0.192 mmol) and 2-cyano-4,5-dimethoxyaniline (48 mg, 0.288 mmol) similar to Example 185 and isolated as a solid (8 mg, 10%). 1H NMR (CDCl3): 9.62 (d, J=1.4 Hz, 1H), 8.69 (m, 2H), 7.43 (dd, J=5.4, 1.5 Hz, 1H), 7.07 (s, 1H), 6.93 (s, 1H), 6.70 (s, 1H).

Sources & evidence

ORD record
ord-03a33a41899542288af1a92f6939c629
Source dataset
uspto-grants-2004_04
Patent number
US06716851B2

Reaction notes

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