4-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidine → HCID 178430730, compound

HRID 2084252Notes

Reaction equation

HRID 2084252 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1.[NH2:18][C:19]1[C:24]([CH3:25])=[CH:23][N:22]=[C:21]([OH:26])[N:20]=1>>[OH:26][C:21]1[N:20]=[C:19]([NH:18][C:2]2[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]3[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=3)[N:3]=2)[C:24]([CH3:25])=[CH:23][N:22]=1

Participants

3

Reactant 2

HCID 14859904-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidineHCID 178430729HCID 178430729, compound

Product 1

HCID 178430730HCID 178430730, compound

Procedure

The title compound was prepared from 4-chloro-2-(3-pyridinyl)-6-trifluoromethylpyrimidine (50 mg, 0.192 mmol) and 4-amino-2-hydroxy-5-methylpyrimidine (36 mg, 0.288 mmol) similar to Example 190 and was isolated as a solid. 1H NMR (CDCl3): 9.47 (brs, 1H), 8.59-8.54 (m, 2H), 7.28 (dd, J=8.1, 5.1 Hz, 1H), 6.59 (s, 1H), 5.18 (s, 2H), 1.70 (s, 3H).

Workup

  1. customwas isolated as a solid

Sources & evidence

ORD record
ord-804b825363074126a4308cc5c87462f9
Source dataset
uspto-grants-2004_04
Patent number
US06716851B2

Reaction notes

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