4-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidine → HCID 9969316, compound

HRID 2084254Notes

Reaction equation

HRID 2084254 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1.[NH2:18][C:19]1[CH:20]=[C:21]2[C:25](=[CH:26][CH:27]=1)[NH:24][C:23]([CH3:28])=[CH:22]2>>[CH3:28][C:23]1[NH:24][C:25]2[C:21]([CH:22]=1)=[CH:20][C:19]([NH:18][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]3[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=3)[N:3]=1)=[CH:27][CH:26]=2

Participants

3

Reactant 2

HCID 14859904-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidineHCID 27339925-Amino-2-methylindole

Product 1

HCID 9969316HCID 9969316, compound

Procedure

The title compound was prepared from 4-chloro-2-(3-pyridinyl)-6-trifluoromethylpyrimidine (50 mg, 0.192 mmol) and 5-amino-2-methylindole (41 mg, 0.288 mmol) similar to Example 190 and was isolated as a solid. 1H NMR (CDCl3): 9.66 (s, 1H), 8.75-8.72 (m, 2H), 8.08 (s, 1H), 7.46-7.34 (m, 4 H), 7.10 (d, J=8.4 Hz, 1H), 6.78 (s, 1H), 6.45 (s, 1H).

Workup

  1. customwas isolated as a solid

Sources & evidence

ORD record
ord-3d15201a9d4a414d906d28f30601b541
Source dataset
uspto-grants-2004_04
Patent number
US06716851B2

Reaction notes

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