Phenol, 5-amino-2,4-dichloro- → HCID 22732498, compound

HRID 2084257Notes

Reaction equation

HRID 2084257 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1.[NH2:18][C:19]1[C:20]([Cl:27])=[CH:21][C:22]([Cl:26])=[C:23]([OH:25])[CH:24]=1>>[Cl:27][C:20]1[CH:21]=[C:22]([Cl:26])[C:23]([OH:25])=[CH:24][C:19]=1[NH:18][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1

Participants

3

Reactant 2

HCID 101471Phenol, 5-amino-2,4-dichloro-HCID 14859904-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 22732498HCID 22732498, compound

Procedure

The title compound was prepared from a mixture of 4-chloro-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol) and 5-amino-2,4-dichlorobenzenol (51 mg, 0.289 mmol) similar to Example 117 and isolated as a white solid (24 mg, 31%). 1H NMR (DMSO-d6): 10.80 (s, 1H), 9.90 (s, 1H), 9.39-9.38 (m, 1H), 8.75-8.72 (m, 1H), 8.57-8.53 (m, 1H), 7.63 (s, 1H), 7.61 (s, 1H), 7.59-7.55 (m, 1H), 7.31 (s, 1H).

Sources & evidence

ORD record
ord-45dea8fc2bf04211bcd1e0fa86408f47
Source dataset
uspto-grants-2004_04
Patent number
US06716851B2

Reaction notes

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