3-(Trifluoromethyl)benzaldehyde → HCID 86587164, compound

HRID 2084269Notes

Reaction equation

HRID 2084269 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[C:12]([C:13]([NH:15][NH2:16])=[O:14])=[CH:11][N:10]=[C:9]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)[N:8]=2)=[CH:3][CH:2]=1.[F:23][C:24]([F:34])([F:33])[C:25]1[CH:26]=[C:27]([CH:30]=[CH:31][CH:32]=1)[CH:28]=O>>[F:23][C:24]([F:33])([F:34])[C:25]1[CH:26]=[C:27]([CH:30]=[CH:31][CH:32]=1)[CH:28]=[N:16][NH:15][C:13]([C:12]1[C:7]([C:4]2[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=2)=[N:8][C:9]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=2)=[N:10][CH:11]=1)=[O:14]

Participants

3

Reactant 2

HCID 679903-(Trifluoromethyl)benzaldehydeHCID 1480512HCID 1480512, compound

Product 1

HCID 86587164HCID 86587164, compound

Procedure

The title compound was prepared from 4-(pyridin-4-yl)-2-(pyridin-2-yl)pyrimidine-5-carboxylic acid-hydrazide and 3-trifluoromethyl-benzaldehyde by a procedure similar to Example 22. 1H NMR (DMSO-d6): 12.38 (s, 1H), 9.30 (s, 1H), 9.22 (s, 1H), 8.84 (m, 1H), 8.78 (d, J=6.0 Hz, 1H), 8.68 (d, J=6.0 Hz, 1H), 8.54 (m, 1H), 8.31 (s, 1H), 8.01 (m, 2H), 7.97 (s, 1H), 7.82 (m, 1H), 7.73 (m, 1H), 7.62 (m, 2H).

Sources & evidence

ORD record
ord-024c6b2344b0449b94326118190f8baa
Source dataset
uspto-grants-2004_04
Patent number
US06716859B2

Reaction notes

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