Sodium Bicarbonate → HCID 22732733, compound

Participants

Reaction Conditions

Reaction Steps

Stannous chloride dihydrate (0.94 g, 4.2 mmol) was added to a solution of 1-(3-nitrophenyl)-3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydroindazole (0.25 g, 0.84 mmol), prepared as described in example 3, in ethanol (5 ml). The reaction mixture was heated at 70° C. for about 1 hour, cooled to room temperature, poured onto ice, neutralized with 5% sodium bicarbonate and extracted with dichloromethane. The combined organic layers were washed with brine, dried over sodium sulfate and evaporated. The residue was chromatographed on silica gel (cyclohexane:ethyl acetate=60:40) to give the title compound as a colourless solid (0.125 g, 60%): m.p. 131-132° C.

Provenance & Evidence