反应详情

A solution of (E)-3-(4-trifluoromethylphenyl)-2-propenamide (17.9 g) and 1,3-dichloroacetone (14.8 g) in toluene (83 ml) was refluxed under heating for 9 hours using a Dean-Stark apparatus. After cooling, water was added; the reaction mixture was extracted with ethyl acetate and washed with saturated saline, after which it was dried over anhydrous magnesium sulfate. After the solvent was distilled off under reduced pressure, the residue was purified by silica gel column chromatography (eluent: hexane-methyl acetate=6:1→5:1) to yield the titled compound (15.1 g) as a colorless needle crystal.

1. temperatureunder heating for 9 hours
2. temperatureAfter cooling
3. extractionthe reaction mixture was extracted with ethyl acetate
4. washwashed with saturated saline
5. dry with materialafter which it was dried over anhydrous magnesium sulfate
6. distillationAfter the solvent was distilled off under reduced pressure
7. customthe residue was purified by silica gel column chromatography (eluent: hexane-methyl acetate=6:1→5:1)