HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dichloroacetone → (E)-4-chloromethyl-2-[2-(2,4-difluorophenyl)ethenyl]oxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dichloroacetone | HCID 10793 | — |
| Reactant | (2E)-3-(2,4-Difluorophenyl)prop-2-enamide | HCID 22259318 | — |
| Product | (E)-4-chloromethyl-2-[2-(2,4-difluorophenyl)ethenyl]oxazole | HCID 12109498 | 49.4% |
Reaction Steps
Using (E)-3-(2,4-difluorophenyl)-2-propenamide (9.16 g) and 1,3-dichloroacetone (7.62 g), the same reaction as Reference Example 1-(ii) was carried out to yield the titled compound (6.31 g) as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716863B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-052aea1cff5548f0a11fc6f74ddbde06 |
| Source note | uspto-grants-2004_04 |