HCID 69831201, compound → HCID 69830277, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (2R)-1-(benzyloxy)-3-(1-trityl-1H-imidazol-2-yl)-2-propanol (1.40 g) in acetone (8 ml), 1 N hydrochloric acid (8 ml) was added, followed by stirring at 50° C. for 1 hour. Additionally, 1 N hydrochloric acid (8 ml) was added, followed by stirring at 50° C. for 2 hours. After concentration and addition of water, the reaction mixture was twice washed with diethyl ether. After neutralization with aqueous sodium bicarbonate, the water layer was extracted with ethyl acetate and washed with saline, after which it was dried over magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent:ethyl acetate-methanol=10:1) to yield the titled compound (424 mg) as a colorless oily substance.

Provenance & Evidence