Sodium Iodide → Benzyl 4-(4-iodobutyl)phenyl ether

HRID 2084369노트

반응식

HRID 2084369 반응식
[I-:1].[Na+].CS(O[CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:14][CH:13]=1)(=O)=O>CC(C)=O>[I:1][CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:14][CH:13]=1

참가 물질

4

반응물 2

HCID 5238Sodium IodideHCID 227333684-[4-(Benzyloxy)phenyl]butyl methanesulfonate

생성물 1

HCID 22259342Benzyl 4-(4-iodobutyl)phenyl ether수율 100.4%

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
80 °C

실험 절차

Sodium iodide (29.25 g) was dissolved in acetone (195 ml); 4-[4-(benzyloxy)phenyl]butyl methanesulfonate (13 g) was added, followed by refluxing at 80° C. for 1.5 hours. After cooling, the solvent was distilled off; to the residue, ethyl acetate (750 ml) was added; the mixture was washed sequentially with water, an aqueous solution of sodium thiosulfate, and saturated saline. The organic layer was dried over anhydrous magnesium sulfate; the solvent was distilled off under reduced pressure to yield the titled compound (14.29 g) as an oily substance. This product was used for the next process without purification.

후처리

  1. temperatureAfter cooling
  2. distillationthe solvent was distilled off
  3. additionto the residue, ethyl acetate (750 ml) was added
  4. washthe mixture was washed sequentially with water
  5. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  6. distillationthe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-65d3037e17204ad4b6560ce3345362a6
출처 데이터셋
uspto-grants-2004_04
특허 번호
US06716863B2

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