反应详情

温度

80 °C

Sodium iodide (29.25 g) was dissolved in acetone (195 ml); 4-[4-(benzyloxy)phenyl]butyl methanesulfonate (13 g) was added, followed by refluxing at 80° C. for 1.5 hours. After cooling, the solvent was distilled off; to the residue, ethyl acetate (750 ml) was added; the mixture was washed sequentially with water, an aqueous solution of sodium thiosulfate, and saturated saline. The organic layer was dried over anhydrous magnesium sulfate; the solvent was distilled off under reduced pressure to yield the titled compound (14.29 g) as an oily substance. This product was used for the next process without purification.

1. temperatureAfter cooling
2. distillationthe solvent was distilled off
3. additionto the residue, ethyl acetate (750 ml) was added
4. washthe mixture was washed sequentially with water
5. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
6. distillationthe solvent was distilled off under reduced pressure