2-(1-(4-[4-(benzyloxy)phenyl]butyl}-1H-imidazol-2-yl)-1-ethanol → 4-[4-[2-(2-hydroxyethyl)-1H-imidazol-1-yl]butyl]phenol

HRID 2084379Notes

Reaction equation

HRID 2084379 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][CH2:18][N:19]2[CH:23]=[CH:22][N:21]=[C:20]2[CH2:24][CH2:25][OH:26])=[CH:11][CH:10]=1)C1C=CC=CC=1>[C].[Pd]>[OH:26][CH2:25][CH2:24][C:20]1[N:19]([CH2:18][CH2:17][CH2:16][CH2:15][C:12]2[CH:11]=[CH:10][C:9]([OH:8])=[CH:14][CH:13]=2)[CH:23]=[CH:22][N:21]=1

Participants

3

Reactant 1

HCID 222593132-(1-(4-[4-(benzyloxy)phenyl]butyl}-1H-imidazol-2-yl)-1-ethanol

Product 1

HCID 222593234-[4-[2-(2-hydroxyethyl)-1H-imidazol-1-yl]butyl]phenolYield 66.9%

Reagents, catalysts & solvents 1

HCID 178418390HCID 178418390, compoundCatalyst

Procedure

Using 2-(1-{4-[4-(benzyloxy)phenyl]butyl}-1H-imidazol-2-yl)-1-ethanol (10.67 g) and 10% palladium carbon (1.6 g), the same reaction as Reference Example 11-(v) was carried out to yield the titled compound (5.3 g).

Workup

  1. customthe same reaction as Reference Example 11-(v)

Sources & evidence

ORD record
ord-7f995a81497f48459b373078cb8ac643
Source dataset
uspto-grants-2004_04
Patent number
US06716863B2

Reaction notes

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