HCID 12109871, compound → HCID 22733371, compound

HRID 2084381Notes

Reaction equation

HRID 2084381 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][N:18]2[CH:22]=[CH:21][N:20]=[C:19]2[CH2:23][CH2:24][OH:25])=[CH:11][CH:10]=1)C1C=CC=CC=1>[C].[Pd]>[OH:25][CH2:24][CH2:23][C:19]1[N:18]([CH2:17][CH2:16][CH2:15][C:12]2[CH:11]=[CH:10][C:9]([OH:8])=[CH:14][CH:13]=2)[CH:22]=[CH:21][N:20]=1

Participants

3

Reactant 1

HCID 12109871HCID 12109871, compound

Product 1

HCID 22733371HCID 22733371, compoundYield 99.9%

Reagents, catalysts & solvents 1

HCID 178418390HCID 178418390, compoundCatalyst

Procedure

Using 2-(1-{3-[4-(benzyloxy)phenyl]propyl}-1H-imidazol-2-yl)-1-ethanol (2.53 g) and 10% palladium carbon (0.38 g), the same reaction as Reference Example 11-(v) was carried out to yield the titled compound (1.85 g) as colorless crystals.

Workup

  1. customthe same reaction as Reference Example 11-(v)

Sources & evidence

ORD record
ord-b5af178a52dc42858977f28b01678d3b
Source dataset
uspto-grants-2004_04
Patent number
US06716863B2

Reaction notes

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