HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 2-(1-{3-[3-(benzyloxy)phenyl]propyl)-1H-imidazol-2-yl)-1-ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-(1H-imidazol-2-yl)ethan-1-ol | HCID 15016080 | — |
| Reactant | Benzyl 3-(3-iodopropyl)phenyl ether | HCID 22733348 | — |
| Product | 2-(1-{3-[3-(benzyloxy)phenyl]propyl)-1H-imidazol-2-yl)-1-ethanol | HCID 22733373 | 78.9% |
Reaction Steps
Using benzyl 3-(3-iodopropyl)phenyl ether (3.53 g), 2-(2-hydroxyethyl)imidazole (1.46 g) and 65% oily sodium hydride (0.48 g), the same reaction as Reference Example 11-(iv) was carried out to yield the titled compound (2.66 g) as a colorless oily substance.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716863B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-8227d41d95204d2db620464d590e24f3 |
| Source note | uspto-grants-2004_04 |