HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 3-{1-[4-(4-benzyloxyphenyl)butyl]-1H-imidazol-2-yl}-1,2-propanediol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Benzyl 4-(4-iodobutyl)phenyl ether | HCID 22259342 | — |
| Reactant | 2-(2,3-Dihydroxypropyl)imidazole | HCID 22733347 | — |
| Product | 3-{1-[4-(4-benzyloxyphenyl)butyl]-1H-imidazol-2-yl}-1,2-propanediol | HCID 22733380 | 57.8% |
Reaction Steps
Using benzyl 4-(4-iodobutyl)phenyl ether (2.05 g), 2-(2,3-dihydroxypropyl)imidazole (1.0 g) and 65% oily sodium hydride (0.259 g), the same reaction as Reference Example 11-(iv) was carried out to yield the titled compound (1.23 g) as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716863B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-d0d76caa46b44eb4922bf49aec29927a |
| Source note | uspto-grants-2004_04 |