3-(1-[3-(3-Benzyloxyphenyl)propyl]-1h-imidazol-2-yl)-1,2-propanediol → 3-{1-[3-(3-hydroxyphenyl)propyl]-1H-imidazol-2-yl)-1,2-propanediol

HRID 2084387Notes

Reaction equation

HRID 2084387 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([CH2:15][CH2:16][CH2:17][N:18]2[CH:22]=[CH:21][N:20]=[C:19]2[CH2:23][CH:24]([OH:27])[CH2:25][OH:26])[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>[C].[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([CH2:15][CH2:16][CH2:17][N:18]2[CH:22]=[CH:21][N:20]=[C:19]2[CH2:23][CH:24]([OH:27])[CH2:25][OH:26])[CH:12]=[CH:13][CH:14]=1

Participants

3

Reactant 1

HCID 227333533-(1-[3-(3-Benzyloxyphenyl)propyl]-1h-imidazol-2-yl)-1,2-propanediol

Product 1

HCID 227333623-{1-[3-(3-hydroxyphenyl)propyl]-1H-imidazol-2-yl)-1,2-propanediolYield 99.9%

Reagents, catalysts & solvents 1

HCID 178418390HCID 178418390, compoundCatalyst

Procedure

Using 3-(1-[3-(3-benzyloxyphenyl)propyl]-1H-imidazol-2-yl}-1,2-propanediol (1.30 g) and 10% palladium carbon (0.195 g), the same reaction as Reference Example 11-(v) was carried out to yield the titled compound (0.979 g) as a colorless oily substance.

Workup

  1. customthe same reaction as Reference Example 11-(v)

Sources & evidence

ORD record
ord-f866bbd056944567bf3d9bd323ccb473
Source dataset
uspto-grants-2004_04
Patent number
US06716863B2

Reaction notes

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