HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 1-{3-[3-({2-[(E)-2-(4-fluorophenyl)ethenyl]-1,3-oxazol-4-yl}methoxy)phenyl]propyl}-1H-1,2,3-triazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-chloromethyl-2-[(E)-2-(4-fluorophenyl)ethenyl]-1,3-oxazole | HCID 12109866 | — |
| Reactant | 3-[3-(1H-1,2,3-Triazole-1-yl)propyl]phenol | HCID 12109869 | — |
| Product | 1-{3-[3-({2-[(E)-2-(4-fluorophenyl)ethenyl]-1,3-oxazol-4-yl}methoxy)phenyl]propyl}-1H-1,2,3-triazole | HCID 22733377 | 88.4% |
Reaction Steps
Using 3-[3-(1H-1,2,3-triazol-1-yl)propyl]phenol(208 mg), 65% oily sodium hydride (39 mg) and 4-(chloromethyl)-2-[(E)-2-(4-fluorophenyl)ethenyl]-1,3-oxazole (250 mg), the same reaction as Example 2 was carried out to yield the titled compound (366 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716863B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-5fd3413917864270be73e5905568717e |
| Source note | uspto-grants-2004_04 |