HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → Mubritinib
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-(chloromethyl)-2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1,3-oxazole | HCID 9857126 | — |
| Reactant | 4-(4-[1,2,3]Triazol-1-yl-butyl)phenol | HCID 12109494 | — |
| Product | Mubritinib | HCID 6444692 | 88.5% |
Reaction Steps
Using 4-[4-(1H-1,2,3-triazol-1-yl)butyl]phenol (152 mg), 65% oily sodium hydride (28 mg) and 4-(chloromethyl)-2-{(E)-2-[4-(trifluoromethyl)phenyl]ethenyl}-1,3-oxazole (212 mg), the same reaction as Example 2 was carried out to yield the titled compound (290 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716863B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-0321a4c1fb164ac69e1266da44c9a0c1 |
| Source note | uspto-grants-2004_04 |