HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 1-{4-[4-({2-[(E)-2-(2,4-difluorophenyl)ethenyl]-1,3-oxazol-4-yl}methoxy)phenyl]butyl}-1H-1,2,3-triazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-(4-[1,2,3]Triazol-1-yl-butyl)phenol | HCID 12109494 | — |
| Reactant | (E)-4-chloromethyl-2-[2-(2,4-difluorophenyl)ethenyl]oxazole | HCID 12109498 | — |
| Product | 1-{4-[4-({2-[(E)-2-(2,4-difluorophenyl)ethenyl]-1,3-oxazol-4-yl}methoxy)phenyl]butyl}-1H-1,2,3-triazole | HCID 12094834 | 83.2% |
Reaction Steps
Using 4-[4-(1H-1,2,3-triazol-1-yl)butyl]phenol (152 mg), 65% oily sodium hydride (28 mg) and 4-(chloromethyl)-2-[(E)-2-(2,4-difluorophenyl)ethenyl]-1,3-oxazole (188 mg), the same reaction as Example 2 was carried out to yield the titled compound (254 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716863B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-d329ed9bc7d7413ca7ca071c8f07fad1 |
| Source note | uspto-grants-2004_04 |