4-[4-[2-(2-hydroxyethyl)-1H-imidazol-1-yl]butyl]phenol → HCID 12094838, compound

HRID 2084398Notes

Reaction equation

HRID 2084398 reaction equation
[OH:1][CH2:2][CH2:3][C:4]1[N:5]([CH2:9][CH2:10][CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=2)[CH:6]=[CH:7][N:8]=1.Cl[CH2:21][C:22]1[N:23]=[C:24](/[CH:27]=[CH:28]/[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[CH3:35])[O:25][CH:26]=1>>[CH3:35][C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=1/[CH:28]=[CH:27]/[C:24]1[O:25][CH:26]=[C:22]([CH2:21][O:19][C:16]2[CH:15]=[CH:14][C:13]([CH2:12][CH2:11][CH2:10][CH2:9][N:5]3[CH:6]=[CH:7][N:8]=[C:4]3[CH2:3][CH2:2][OH:1])=[CH:18][CH:17]=2)[N:23]=1

Participants

3

Reactant 2

HCID 222593234-[4-[2-(2-hydroxyethyl)-1H-imidazol-1-yl]butyl]phenolHCID 22733360HCID 22733360, compound

Product 1

HCID 12094838HCID 12094838, compoundYield 62.1%

Procedure

Using 4-[4-[2-(2-hydroxyethyl)-1H-imidazol-1-yl]butyl]phenol (153 mg) and (E)-4-chloromethyl-2-[2-(2-methylphenyl)ethenyl]oxazole (151 mg), the same reaction as Example 1 was carried out to yield the titled compound (167 mg) as colorless crystals.

Workup

  1. customthe same reaction as Example 1

Sources & evidence

ORD record
ord-126d75e1f25d45699029ef44dee3f070
Source dataset
uspto-grants-2004_04
Patent number
US06716863B2

Reaction notes

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