HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 2-(1-(4-[4-({2-[(E)-2-(4-fluorophenyl)ethenyl]-1,3-oxazol-4-yl}methoxy)phenyl]butyl)-1H-imidazol-2-yl)-1-ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-chloromethyl-2-[(E)-2-(4-fluorophenyl)ethenyl]-1,3-oxazole | HCID 12109866 | — |
| Reactant | 4-[4-[2-(2-hydroxyethyl)-1H-imidazol-1-yl]butyl]phenol | HCID 22259323 | — |
| Product | 2-(1-(4-[4-({2-[(E)-2-(4-fluorophenyl)ethenyl]-1,3-oxazol-4-yl}methoxy)phenyl]butyl)-1H-imidazol-2-yl)-1-ethanol | HCID 12094840 | 84.1% |
Reaction Steps
Using 4-[4-[2-(2-hydroxyethyl)-1H-imidazol-1-yl]butyl]phenol (391 mg), 65% oily sodium hydride (60 mg) and 4-(chloromethyl)-2-((E)-2-(4-fluorophenyl)ethenyl]-1,3-oxazole (375 mg), the same reaction as Example 2 was carried out to yield the titled compound (583 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716863B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-3f76f7fdd1a74e43a2b373b599bb321c |
| Source note | uspto-grants-2004_04 |