HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 3-(1-{4-[4-({2-[(E)-2-(4-fluorophenyl)ethenyl]-1,3-oxazol-4-yl}methoxy)phenyl]butyl}-1H-imidazol-2-yl)-1,2-propanediol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-chloromethyl-2-[(E)-2-(4-fluorophenyl)ethenyl]-1,3-oxazole | HCID 12109866 | — |
| Reactant | 3-{1-[4-(4-hydroxyphenyl)butyl]-1H-imidazol-2-yl)-1,2-propanediol | HCID 12109872 | — |
| Product | 3-(1-{4-[4-({2-[(E)-2-(4-fluorophenyl)ethenyl]-1,3-oxazol-4-yl}methoxy)phenyl]butyl}-1H-imidazol-2-yl)-1,2-propanediol | HCID 12109496 | 70.4% |
Reaction Steps
Using 3-{1-[4-(4-hydroxyphenyl)butyl]-1H-imidazol-2-yl}-1,2-propanediol (291 mg), 65% oily sodium hydride (39 mg) and 4-(chloromethyl)-2-[(E)-2-(4-fluorophenyl)ethenyl]-1,3-oxazole (250 mg), the same reaction as Example 2 was carried out to yield the titled compound (347 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716863B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-640550e6a1534bcdb4f2e1be5e4ccadc |
| Source note | uspto-grants-2004_04 |