HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 3-[1-(4-(4-[(2-{(E)-2-[4-(trifluoromethyl)phenyl]ethenyl)-1,3-oxazol-4-yl)methoxy]phenyl}butyl)-1H-imidazol-2-yl]-1,2-propanediol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-(chloromethyl)-2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1,3-oxazole | HCID 9857126 | — |
| Reactant | 3-{1-[4-(4-hydroxyphenyl)butyl]-1H-imidazol-2-yl)-1,2-propanediol | HCID 12109872 | — |
| Product | 3-[1-(4-(4-[(2-{(E)-2-[4-(trifluoromethyl)phenyl]ethenyl)-1,3-oxazol-4-yl)methoxy]phenyl}butyl)-1H-imidazol-2-yl]-1,2-propanediol | HCID 12109497 | 74.9% |
Reaction Steps
Using 3-{1-[4-(4-hydroxyphenyl)butyl]-1H-imidazol-2-yl}-1,2-propanediol (204 mg), 65% oily sodium hydride (28 mg) and 4-(chloromethyl)-2-{(E)-2-[4-(trifluoromethyl)phenyl]ethenyl}-1,3-oxazole (212 mg), the same reaction as Example 2 was carried out to yield the titled compound (285 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716863B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-118a3269d8a64cb98d1f9b8ccf139c68 |
| Source note | uspto-grants-2004_04 |