HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 3-(1-{3-[3-({2-[(E)-2-(2,4-difluorophenyl)ethenyl]-1,3-oxazol-4-yl}methoxy)phenyl]propyl}1H-imidazol-2-yl)-1,2-propanediol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | (E)-4-chloromethyl-2-[2-(2,4-difluorophenyl)ethenyl]oxazole | HCID 12109498 | — |
| Reactant | 3-{1-[3-(3-hydroxyphenyl)propyl]-1H-imidazol-2-yl)-1,2-propanediol | HCID 22733362 | — |
| Product | 3-(1-{3-[3-({2-[(E)-2-(2,4-difluorophenyl)ethenyl]-1,3-oxazol-4-yl}methoxy)phenyl]propyl}1H-imidazol-2-yl)-1,2-propanediol | HCID 22733369 | 60.4% |
Reaction Steps
Using 3-{1-[3-(3-hydroxyphenyl)propyl]-1H-imidazol-2-yl}-1,2-propanediol (203 mg), 65% oily sodium hydride (29 mg) and 4-(chloromethyl)-2-[(E)-2-(2,4-difluorophenyl)ethenyl]-1,3-oxazole (197 mg), the same reaction as Example 2 was carried out to yield the titled compound (220 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716863B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-f7ba0e5b03444386bc6aa59a19c0d86f |
| Source note | uspto-grants-2004_04 |