HuagongsheHuagongshe Chemistry Print Report · For research reference only
Semaxinib → 2-{(3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)-methylidene]-2-oxo-2,3-dihydro-1H-indol-1-yl}-N,N,N-trimethyl-2-oxo-1-ethanaminium chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Semaxinib | HCID 123015 | — |
| Reactant | N-Chlorobetainyl chloride | HCID 11052093 | — |
| Product | 2-{(3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)-methylidene]-2-oxo-2,3-dihydro-1H-indol-1-yl}-N,N,N-trimethyl-2-oxo-1-ethanaminium chloride | HCID 10292758 | — |
Reaction Steps
The title compound was prepared from 3-(3,5-dimethyl-1H-pyrrol-2-ylmethylidene)-1,3-dihydro-indol-2-one and 2-chloro-N,N,N-trimethyl-2-oxoethanaminium chloride (modification of procedure used to prepare (3Z)-1-acetyl-3-[(3,5-dimethyl-4-1H-pyrrol-2-yl)-methylidene]-1,3-dihydro-2H-indol-2-one (15)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716870B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-6ee5e92a5c2a4a64b70321b030458a62 |
| Source note | uspto-grants-2004_04 |