HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine-2-sulfonyl Chloride → tert-butyl(3R)-6-cyclohexyl-3-(3-{[(2-pyridinylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine-2-sulfonyl Chloride | HCID 3787675 | — |
| Reactant | tert-butyl(3R)-3-[3-(aminomethyl)-1,2,4-oxadiazol-5-yl]-6-cyclohexylhexanoate | HCID 16747946 | — |
| Product | tert-butyl(3R)-6-cyclohexyl-3-(3-{[(2-pyridinylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanoate | HCID 16748331 | — |
Reaction Steps
Method same as for preparation 10 using tert-butyl (3R)-3-[3-(aminomethyl)-1,2,4-oxadiazol-5-yl]-6-cyclohexylhexanoate (preparation 18) (210 mg, 057 mmol) and 2-pyridinesulphonylchloride (J. Med. Chem; 1997, 40, 1149) (170 mg, 0.96 mmol) as starting materials.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716861B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-662b32111cd24e6aace7032ca30f4847 |
| Source note | uspto-grants-2004_04 |