Phosphorus pentachloride → 1H-pyrazole-4-sulfonyl chloride
Reaction equation
[NH:1]1[CH:5]=[C:4]([S:6]([OH:9])(=O)=[O:7])[CH:3]=[N:2]1.P(Cl)(Cl)(Cl)(Cl)[Cl:11]>C1(C)C=CC=CC=1>[NH:1]1[CH:5]=[C:4]([S:6]([Cl:11])(=[O:9])=[O:7])[CH:3]=[N:2]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 180 °C
Procedure
A mixture of 1H-pyrazole-4-sulfonic acid (J. Am. Chem. Soc.; 1955, 77, 6532) (1.0 g, 4.0 mmol) and phosphorous pentachloride (1.6 g, 7.7 mmol) were heated up to 180° C. over the period of an hour. The mixture began to reflux but not fully molten. The reaction mixture was cooled to 130° C. and toluene (5 ml) was added and allowed to cool to room temperature with stirring. The white solid was filtered off. The filtrate solvent was removed under reduced pressure and azeotroped with toluene and DCM to afford the title compound as a colourless oil and impure.
Workup
- temperatureto reflux
- temperatureThe reaction mixture was cooled to 130° C.
- temperatureto cool to room temperature
- filtrationThe white solid was filtered off
- customThe filtrate solvent was removed under reduced pressure
- customazeotroped with toluene and DCM
Sources & evidence
- ORD record
- ord-e63cad7c3fa5483ebcc22c8a4e18a039
- Source dataset
- uspto-grants-2004_04
- Patent number
- US06716861B2
Reaction notes
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