(2R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-cyclohexylpentanoic acid → HCID 16749008, compound

HRID 2084453Notes

Reaction equation

HRID 2084453 reaction equation
[C:1]([O:5][C:6](=[O:21])[CH2:7][C@@H:8]([CH2:12][CH2:13][CH2:14][CH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)[C:9]([OH:11])=[O:10])([CH3:4])([CH3:3])[CH3:2].O/[N:23]=[C:24](\[NH2:32])/[CH2:25][CH2:26][NH:27][S:28]([CH3:31])(=[O:30])=[O:29]>>[NH2:32]/[C:24](=[N:23]\[O:10][C:9](=[O:11])[C@H:8]([CH2:12][CH2:13][CH2:14][CH:15]1[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]1)[CH2:7][C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:21])/[CH2:25][CH2:26][NH:27][S:28](=[O:30])(=[O:29])[CH3:31]

Participants

3

Reactant 2

HCID 9835906(2R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-cyclohexylpentanoic acidHCID 22733172HCID 22733172, compound

Product 1

HCID 16749008HCID 16749008, compound

Procedure

Method as for preparation 2 using (2R)-2-(2-tert-butoxy-2-oxoethyl)-5-cyclohexylpentanoic acid (preparation 168) (670 mg, 2.25 mmol) and (1Z)-N′-hydroxy-3-[(methylsulfonyl)amino]propanimidamide (preparation 30) (700 mg, 2.50 mmol) as starting materials to afford the title compound as a yellow oil.

Sources & evidence

ORD record
ord-26fbd440d7d349d0a7580b42bd013980
Source dataset
uspto-grants-2004_04
Patent number
US06716861B2

Reaction notes

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