HCID 60077664, compound → HCID 60077679, compound

Participants

Reaction Steps

A solution of tert-butyl (3R)-3-[({[(Z)-amino(1-benzhydryl-3-azetidinyl)methylidene]amino}oxy)carbonyl]-6-cyclohexylhexanoate (preparation 35) (2.85 g, 5.07 mmol) in toluene (90 ml) was heated at 140° C. under Dean and Stark conditions for 18 hours. The reaction mixture was allowed to cool to room temperature. The solvent was removed under reduced pressure. The residue was purified on a silica column eluting with a solvent gradient of cyclohexane:Et2O (90:10) gradually changing to (60:40) to afford the title compound as a colourless oil (2.0 g, 73%).

Provenance & Evidence