HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromoacetamide → tert-butyl(3R)-3-(3-{[(2-amino-2-oxoethyl)(methyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-6-cyclohexylhexanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromoacetamide | HCID 69632 | — |
| Reactant | tert-butyl(3R)-6-cyclohexyl-3-{3-[(methylamino)methyl]-1,2,4-oxadiazol-5-yl}hexanoate | HCID 16747948 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | tert-butyl(3R)-3-(3-{[(2-amino-2-oxoethyl)(methyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-6-cyclohexylhexanoate | HCID 60077632 | 104.6% |
Reaction Steps
Method as for preparation 106 using tert-butyl (3R)-6-cyclohexyl-3-{3-[(methylamino)methyl]-1,2,4-oxadiazol-5-yl}hexanoate (preparation 5) (244 mg, 0.67 mmol) and 2-bromoacetamide (95 mg, 0.69 mmol) as starting materials and Et3N as the base to afford the title compound as a colourless oil (296 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716861B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-3371bad9e57d4340b644d070bff09b8f |
| Source note | uspto-grants-2004_04 |