Morpholine → HCID 60077628, compound

HRID 2084503Notes

Reaction equation

[CH2:1]([O:8][NH:9][C:10](=[O:30])[CH2:11][C@H:12]([C:22]1[O:23][C:24]([CH3:29])=[C:25]([CH:27]=O)[N:26]=1)[CH2:13][CH2:14][CH2:15][CH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:31]1[CH2:36][CH2:35][O:34][CH2:33][CH2:32]1>>[CH2:1]([O:8][NH:9][C:10](=[O:30])[CH2:11][C@H:12]([C:22]1[O:23][C:24]([CH3:29])=[C:25]([CH2:27][N:31]2[CH2:36][CH2:35][O:34][CH2:33][CH2:32]2)[N:26]=1)[CH2:13][CH2:14][CH2:15][CH:16]1[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 8083Morpholine

HCID 60077624HCID 60077624, compound

Product 1

HCID 60077628HCID 60077628, compound

Procedure

Method as for preparation 157 using (3R)-N-(benzyloxy)-6-cyclohexyl-3-(4-formyl-5-methyl-1,3-oxazol-2-yl)hexanamide (preparation 160) (300 mg, 0.73 mmol) and morpholine (64 μl, 0.73 mmol) as starting materials.

Sources & evidence

ORD record: ord-9d63174ae7ce4894867bf894de8bcb97
Source dataset: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06716861B2

Reaction notes

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