HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-phenylpentanoic acid → (2R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-cyclohexylpentanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-phenylpentanoic acid | HCID 10803584 | — |
| Catalyst | Rhodium | HCID 23948 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (2R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-cyclohexylpentanoic acid | HCID 9835906 | 89.4% |
Reaction Steps
A solution of (R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-phenylpentanoic acid (2.2 g, 7.5 mmol) and 5%Rh/C (0.22 g) in methanol (220 ml) was stirred at room temperature, under hydrogen (150 p.s.i.) for 24 hours and then filtered through celite. The filtrate was concentrated in vacuo to leave the title compound as an oil (2.0 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716861B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-e77f508a86fa43b8a6fd469a148dff5e |
| Source note | uspto-grants-2004_04 |