HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-(Cyclopropylmethoxy)-4-methoxybenzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Isovanillin | HCID 12127 | — |
| Reactant | Bromomethylcyclopropane | HCID 81503 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-(Cyclopropylmethoxy)-4-methoxybenzaldehyde | HCID 22246623 | — |
Reaction Steps
A solution of 3-hydroxy-4-methoxybenzaldehyde (400 g, 2.63 mole)and bromomethylcyclopropane (426 g, 3.2 mole) in 1 L dimethylformamide (DMF) was stirred with potassium carbonate (K2CO3) (483 g, 3.5 mole) at 55° C. for 3.5 h. Then, 1 L of water was added, the mixture chilled on ice, and Intermediate 1 filtered as a white solid, (535 g, 99%). m/z 207 (MH+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716871B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-3b9b97b586a64f9fbc71d44d4c09bfaa |
| Source note | uspto-grants-2004_04 |