反应详情

The ester obtained in Step D (76.18 mmol) and 57.1 ml of 2N sodium hydroxide (114.27 mmol, 1.5 eq.) are stirred in 240 ml of acetone at room temperature for 24 hours. The solvents are removed by evaporation and the residue is taken up in water. The aqueous phase is extracted with ether and then rendered acidic with 3N HCl and finally extracted with ether. The organic phase is washed with water, with saturated NaCl, dried over Na2SO4 and then concentrated under reduced pressure to yield the title acid.

1. customThe solvents are removed by evaporation
2. extractionThe aqueous phase is extracted with ether
3. extractionfinally extracted with ether
4. washThe organic phase is washed with water, with saturated NaCl
5. dry with materialdried over Na2SO4
6. concentrationconcentrated under reduced pressure