Ethyl pyruvate → 4-amino-6-methyl-7(8H)-pteridone

Participants

Reaction Steps

More specifically, with reference to FIG. 2, 4,5,6-triaminopyrimidine (1), (see, J. Baddiley et al., J. Chem. Soc. 386 (1943)) and ethyl pyruvate are heated in glacial acetic acid for 2 hours. After cooling the precipitate is collected and washed with water and purified by recrystallization using a suitable solvent system, such as DMF/H2O, to yield 4-amino-6-methyl-7(8H)-pteridone (3) (see, D. Söll et al., Chem. Ber. 96:2977 (1963)). Compounds wherein R1 is an methyl group can be generated similarly by starting with 4,5,triamino-2-methylpyrimidine (2).

Provenance & Evidence