反应详情

1-[5′-(3″-t-butoxycarbonylaminopropyloxy)-2′-nitrophenyl)-2-propen-1-one (325 mg) is dissolved in ethanol (15 ml) and thereto is added 10% palladium-carbon (40 mg), and the mixture is stirred under hydrogen atmosphere for 1.5 hour. After removing the catalyst by filtration, the filtrate is concentrated and purified with a silica gel column chromatography to give 1-[5′-(3″-t-butoxycarbonylaminopropyloxy)-2′-aminophenyl]propan-1-one (248 mg) as yellow powders.

1. customAfter removing the catalyst
2. filtrationby filtration
3. concentrationthe filtrate is concentrated
4. custompurified with a silica gel column chromatography