HRID2084600

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1c(O[Si](C(C)C)(C(C)C)C(C)C)cccc1C(OC(=O)C(OC)c1ccccc1)C1CCN(CCc2ccc(F)cc2)CC1

HCID21305588

未命名化合物

结构：[F-].[F-].[F-].[F-].[NH4+].[NH4+].[NH4+].[NH4+]

HCID22393694

未命名化合物

PRODUCTS

生成物

结构：COc1c(O)cccc1C(OC(=O)[C@@H](OC)c1ccccc1)C1CCN(CCc2ccc(F)cc2)CC1

HCID60077790

未命名化合物

PROCEDURE

实验过程

Add to methoxy-phenyl-acetic acid {1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-(2-methoxy-3-triisopropylsilanyloxy-phenyl)-methyl ester, Example 1C (207 g, 0.3111 mol) a 0.5M solution of methanolic ammonium tetrafluoride (1.2 L, 0.6 mol) and reflux for 17.5 h. Concentrate and obtain 198 g of the title compound.

WORKUP

后处理

temperaturereflux for 17.5 h
concentrationConcentrate

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4719a8e93c934cb0b5a152a129e6b25a
来源数据集: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06716986B2
来源说明: uspto-grants-2004_04

反应 SMILES

[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([CH:16]([O:36][C:37](=[O:47])[CH:38]([O:45][CH3:46])[C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=3)[C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([O:23][Si](C(C)C)(C(C)C)C(C)C)[C:18]=3[O:34][CH3:35])[CH2:12][CH2:11]2)=[CH:4][CH:3]=1.[F-].[F-].[F-].[F-].[NH4+].[NH4+].[NH4+].[NH4+]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([CH:16]([O:36][C:37](=[O:47])[C@@H:38]([O:45][CH3:46])[C:39]3[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=3)[C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([OH:23])[C:18]=3[O:34][CH3:35])[CH2:12][CH2:11]2)=[CH:4][CH:3]=1