Sodium Bicarbonate → HCID 9930379, compound

Participants

Reaction Steps

Stir and cool in an ice bath under nitrogen, 4-(2-methoxy-3-triisopropylsilanyloxy-benzoyl)-piperidine-1-carboxylic acid tert-butyl ester, Example 2B (5.71 g, 11.6 mmol) and add trifluoroacetic acid (30 mL). Remove the cold bath after 10 minutes. After 2 h, concentrate the reaction under vacuum at 40-45° C. and then pour into saturated aqueous NaHCO3. Extract the basic layer with CH2Cl2 (2×200 mL), dry (Na2SO4), and concentrate under vacuum to an oil, which eventually solidifies to afford 4-(2-methoxy-3-triisopropylsilanyloxy-benzoyl)-piperidine.

Provenance & Evidence