HCID 86588272, compound → HCID 86588271, compound

HRID 2084687Notes

Reaction equation

HRID 2084687 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([O:11][CH2:12][C@H:13]([O:16][C:17]2[C:25](/[CH:26]=C/C)=[CH:24][CH:23]=[C:22]3[C:18]=2[CH:19]=[CH:20][N:21]3[S:29]([C:32]2[CH:37]=[CH:36][C:35]([CH3:38])=[CH:34][CH:33]=2)(=[O:31])=[O:30])[CH:14]=C)(=[O:10])=[O:9])=[CH:4][CH:3]=1>ClCCl.C(=[Ru+2])C1C=CC=CC=1.C1(P(C2CCCC2)C2CCCC2)CCCC1.C1(P(C2CCCC2)C2CCCC2)CCCC1>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([O:11][CH2:12][C@@H:13]2[O:16][C:17]3=[C:18]4[C:22](=[CH:23][CH:24]=[C:25]3[CH:26]=[CH:14]2)[N:21]([S:29]([C:32]2[CH:33]=[CH:34][C:35]([CH3:38])=[CH:36][CH:37]=2)(=[O:30])=[O:31])[CH:20]=[CH:19]4)(=[O:10])=[O:9])=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 86588272HCID 86588272, compound

Product 1

HCID 86588271HCID 86588271, compound

Reagents, catalysts & solvents 2

HCID 178420527HCID 178420527, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

Treatment of (2R)-2-({1-[(4-methylphenyl)sulfonyl]-5-[(1E)-prop-1-enyl]-1H-indol-4-yl}oxy)but-3-enyl 4-methylbenzenesulfonate with bis(tricyclopentyl-phosphine) benzylidene ruthenium (IV) in dichloromethane under the conditions described for Example 1b gives {(2R)-7-[(4-methylphenyl)sulfonyl]-2,7-dihydropyrano[2,3-e]indol-2-yl}methyl 4-methylbenzenesulfonate.

Sources & evidence

ORD record
ord-f602b95a15c34ce6b68082cd3cc64fff
Source dataset
uspto-grants-2004_04
Patent number
US06716998B2

Reaction notes

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