Sodium Hydroxide → HCID 22734078, compound

HRID 2084784Notes

Reaction equation

HRID 2084784 reaction equation
[CH3:1][C:2]1([CH3:23])[CH2:6][C:5]2[C:7]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([O:21]C)=[O:20])[CH:14]=3)=[CH:8][CH:9]=[C:10]([O:11][CH3:12])[C:4]=2[O:3]1.[OH-].[Na+]>C(O)C>[C:19]([C:15]1[CH:14]=[C:13]([C:7]2[C:5]3[CH2:6][C:2]([CH3:1])([CH3:23])[O:3][C:4]=3[C:10]([O:11][CH3:12])=[CH:9][CH:8]=2)[CH:18]=[CH:17][CH:16]=1)([OH:21])=[O:20]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 22734460HCID 22734460, compound

Product 1

HCID 22734078HCID 22734078, compoundYield 92.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of Compound 146 (1.3 g) obtained in Example 146, a 4N aqueous solution (10.4 ml) of sodium hydroxide, and ethanol (50 ml) was stirred at room temperature for 3 hours. The solvent was removed and the residue was dissolved in water. Concentrated hydrochloric acid was dropwise added to the solution, and the generated precipitate was collected by filtration, washed with water, and dried to give Compound 147 (1.15 g, 92.7%) as white crystals.

Workup

  1. customThe solvent was removed
  2. dissolutionthe residue was dissolved in water
  3. additionConcentrated hydrochloric acid was dropwise added to the solution
  4. filtrationthe generated precipitate was collected by filtration
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-9bb6fb653dc3432aa5fc518d5edab787
Source dataset
uspto-grants-2004_04
Patent number
US06716987B1

Reaction notes

Loading…