Water → HCID 22734450, compound

HRID 2084794Notes

Reaction equation

HRID 2084794 reaction equation
C([O:3][C:4]([C:6]1[CH:7]=[C:8]([NH:12][C:13]([C:15]2[C:24]3[O:23][CH2:22][CH2:21][O:20][C:19]=3[C:18]([O:25][CH3:26])=[CH:17][CH:16]=2)=[O:14])[CH:9]=[CH:10][CH:11]=1)=[O:5])C.[OH-].[Na+].O.O.Cl>C(O)C>[C:4]([C:6]1[CH:7]=[C:8]([NH:12][C:13]([C:15]2[C:24]3[O:23][CH2:22][CH2:21][O:20][C:19]=3[C:18]([O:25][CH3:26])=[CH:17][CH:16]=2)=[O:14])[CH:9]=[CH:10][CH:11]=1)([OH:5])=[O:3]

Participants

6

Reactant 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 21885828Hydrate;hydrochlorideHCID 22734091HCID 22734091, compound

Product 1

HCID 22734450HCID 22734450, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Compound 185 (0.19 g) obtained in Example 185 was suspended in ethanol (1 ml), mixed with a 24% aqueous sodium hydroxide solution (1.3 ml), and heat-refluxed for 2 hours. The resultant was allowed to stand for cooling, mixed with water, and adjusted to PH 2 by adding 2N hydrochloric acid water. The precipitated solid was collected by filtration to give Compound 186(0.14 g, 80%) as colorless crystals.

Workup

  1. temperatureheat-refluxed for 2 hours
  2. temperaturefor cooling
  3. filtrationThe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-14fd2bd3484242a8a55eb0196dc3ebba
Source dataset
uspto-grants-2004_04
Patent number
US06716987B1

Reaction notes

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