Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 3-Chloro-2-methyl-1-propene | HCID 11241 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Bromo-2-methoxyphenol | HCID 142228 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 22734142 | HCID 22734142 | — |
Reaction Steps
A mixture of 5-bromo-2-methoxyphenol (17.8 g), 3-chloro-2-methyl-1-propene (13.0 ml), potassium carbonate (18.2 g), and DMF (150 ml) was stirred at 80° C. for 2 hours. The mixture was diluted with toluene, washed with a saturated saline and dried over anhydrous magnesium sulfate, and the solvent was distilled off to give Compound IIa-a (22.2 g, 98.4%) as a colorless oily substance.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06716987B1 |
|---|
| Source dataset | uspto-grants-2004_04 |
|---|
| ORD ID | ord-c5eeb0086b474d32a7192f4da044e17c |
|---|
| Source note | uspto-grants-2004_04 |
|---|
