Alanine, ethyl ester, hydrochloride (1:1) → HCID 54383343, compound

HRID 2084845Notes

Reaction equation

HRID 2084845 reaction equation
Cl.[CH2:2]([O:4][C:5](=[O:9])[CH:6]([CH3:8])[NH2:7])[CH3:3].[CH2:10]([O:14][C:15]1[CH:20]=[CH:19][C:18]([S:21](Cl)(=[O:23])=[O:22])=[CH:17][CH:16]=1)[C:11]#[C:12][CH3:13]>>[CH2:2]([O:4][C:5](=[O:9])[CH:6]([NH:7][S:21]([C:18]1[CH:17]=[CH:16][C:15]([O:14][CH2:10][C:11]#[C:12][CH3:13])=[CH:20][CH:19]=1)(=[O:23])=[O:22])[CH3:8])[CH3:3]

Participants

3

Reactant 2

HCID 102560Alanine, ethyl ester, hydrochloride (1:1)HCID 111959284-But-2-ynyloxy-benzenesulfonyl chloride

Product 1

HCID 54383343HCID 54383343, compoundYield 58%

Procedure

According to the procedure of Example 20, 1.00 g (6.51 mmol) of D,L-alanine ethyl ester hydrochloride reacted with 1.75 g (7.16 mmol) of 4-but-2-ynyloxy-benzenesulfonyl chloride to provide 1.22 g (58%) of the sulfonamide as a white solid. Electrospray Mass Spec: 325.9 (M+H)+.

Sources & evidence

ORD record
ord-ad9fdce9cf304e028838c2eed34a4df0
Source dataset
uspto-grants-2004_04
Patent number
US06716833B2

Reaction notes

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