4-But-2-ynyloxy-benzenesulfonyl chloride → HCID 44404794, compound

HRID 2084854Notes

Reaction equation

HRID 2084854 reaction equation
[CH2:1]([O:3][C:4]([CH:6]1[NH:11][CH2:10][CH2:9][N:8]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:7]1)=[O:5])[CH3:2].[CH2:19]([O:23][C:24]1[CH:29]=[CH:28][C:27]([S:30](Cl)(=[O:32])=[O:31])=[CH:26][CH:25]=1)[C:20]#[C:21][CH3:22]>>[CH2:1]([O:3][C:4]([CH:6]1[N:11]([S:30]([C:27]2[CH:26]=[CH:25][C:24]([O:23][CH2:19][C:20]#[C:21][CH3:22])=[CH:29][CH:28]=2)(=[O:32])=[O:31])[CH2:10][CH2:9][N:8]([C:12]([O:14][C:15]([CH3:17])([CH3:16])[CH3:18])=[O:13])[CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 111959284-But-2-ynyloxy-benzenesulfonyl chlorideHCID 114026711-tert-Butyl 3-ethyl piperazine-1,3-dicarboxylate

Product 1

HCID 44404794HCID 44404794, compoundYield 72%

Procedure

According to the procedure of Example 51, 1.55 g (5.99 mmol) of the product of Example 50 and 1.61 g (6.59 mmol) of 4-but-2-ynyloxy-benzenesulfonyl chloride provided 1.96 g (72%) of the sulfonamide as a white solid. Electrospray Mass Spec 467.0 (M+H)+.

Sources & evidence

ORD record
ord-b403e0e3b8be4263b6ec0269fe67119d
Source dataset
uspto-grants-2004_04
Patent number
US06716833B2

Reaction notes

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